1. Signaling Pathways
  2. Metabolic Enzyme/Protease
  3. 5 alpha Reductase

5 alpha Reductase (5α-还原酶)

5α-reductase

类固醇 5-α 还原酶 (5AR) 是一种膜结合蛋白,负责将类固醇(例如睾酮、孕酮和雄烯二酮)还原为 5-α 还原代谢物,例如 5-α 双氢睾酮 (DHT)、5-α 双氢孕酮和雄烯二酮。人类中有三种 5AR 同工酶:SRD5A1、SRD5A2 和 SRD5A3。SRD5A1 和 SRD5A2 具有 5-α 还原人类类固醇的功能。DHT 是一种比睾酮更有效的雄激素,在雄激素受体激活中发挥作用。

5αR2 的失活突变会导致性发育障碍。5AR的调控对于良性前列腺增生(BPH)和前列腺癌(PC)的治疗具有重要意义,5AR抑制剂被广泛应用于治疗雄激素依赖性的良性或恶性前列腺疾病。

Steroid 5-α reductase (5AR) is a membrane-bound protein that is responsible for reducing steroids such as testosterone, progesterone, and androstenedione to 5-α reduced metabolites such as 5-α dihydrotestosterone (DHT), 5-α dihydroprogesterone and androstanedione, respectively. There are three isoforms of 5AR in humans: SRD5A1, SRD5A2, and SRD5A3. SRD5A1 and SRD5A2 have functionality for 5-α reduction of steroids in humans. DHT is a more potent androgen than testosterone and has a function in androgen receptor activation.

The inactivating mutations in 5αR2 lead to disorders of sexual development. The regulation of 5AR is important for the treatment of benign prostate hyperplasia (BPH) and prostate cancer (PC), and 5AR inhibitors are widely used for the treatment of androgen-dependent benign or malignant prostatic diseases.

5 alpha Reductase 相关产品 (42):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-123323
    MK-0434 Inhibitor
    MK-0434 是一种具有口服活性的类固醇 5α-还原酶 (steroid 5α-reductase) 抑制剂。MK-0434 特异性抑制 5α-还原酶 (steroid 5α-reductase),从而减少体内二氢睾酮 (DHT) 的水平。MK-0434 可用于良性前列腺增生的研究。
    MK-0434
  • HY-U00376
    5α-reductase-IN-1 Inhibitor
    5α-reductase-IN-1 是一种 5α-reductase 抑制剂,可与 minoxidil 混合使用,研究脱发症状。
    5α-reductase-IN-1